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A hypersensitivity (allergic) reaction in which IgE antibodies attach to mast cells and basophils, causing them to produce mediators of anaphylaxis (histamine, leukotrienes, kinins, and prostaglandins) that bring about increased blood permeability, increased smooth muscle contraction, and increased mucus production. Examples are hay fever, hives and anaphylactic shock. (1)
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