End the overwhelm.

Get a head start with my researched and field tested tool kit so that your child can thrive too.

End the overwhelm.

Get a head start with my researched and field tested tool kit so that your child can thrive too.


Detox Step One: Reducing Child Exposure to Toxicants

Table of Contents


When parents first learn about the potential negative effects of the exposure to toxicants and the impaired detoxification processes in their children with neurodevelopmental disorders, a feeling of dread can set in. The sheer volume of toxicants we humans come into contact with every day is enough to overwhelm anyone from taking action. Let's take a detailed look in this blog, Detox Step One: Reducing Child Exposure to Toxicants, so you can see how even small changes add up to a big impact when it comes to your child’s health.

It’s easy to get so caught up thinking about how to clear toxins from our children's bodies that we forget the detox step one: removing as many of the toxicants from their daily lives and immediate environment as possible. Our bodies have built-in detox systems, but in children with neurodevelopmental disorders, these systems may not be working very well. So reducing their initial exposure is often critical to recovery.

This is no easy feat, as I mentioned above. We are potentially exposed to tens of thousands of toxicants, very few of which have been studied to determine their effects on human health. To make matters worse, toxicants that have been deemed to be “safe” at certain levels of exposure have never been tested alongside other “safe” toxicants to determine the synergistic impact on health. These studies would be difficult, if not impossible, to conduct given the number of potential combinations of different toxicants that would need to be included. And yet we are exposed to a wide range of toxicants in combination every single day.

Toxicants can be found in the air we breathe, the soil our food is grown in, the food we eat, the water we drink and even in the mattress your child sleeps on which is why it is very important to understand our detox step one. The ubiquity of these toxicants can be downright depressing. Reducing the toxicant burden on our child is the crucial first step towards decreasing their total body burden.

in a nutshell
  • Toxicants are all around us, so we must work to minimize or eliminate the exposures wherever possible for our child.
  • Children with neurodevelopmental disorders are more sensitive to toxicant exposure because they typically have impaired detox systems, so their bodies are unable to properly clear toxicants.
  • An updated review published in the Lancet journal has identified eleven widely used industrial toxicants that are known to cause developmental neurotoxicity. 1
  • Other toxicants, such as plastics, have also been shown to be endocrine disruptors, which impair hormone function and deplete intracellular glutathione, further interfering with the body’s ability to detoxify.
  • Do a home and school environment inventory to see where your child’s greatest exposures may be and what you can do to minimize them.

Toxins and Toxicants—What Are They and Where Are They?

There are two basic types of toxins that need to be detoxed or eliminated from our bodies in order to maintain or promote health which is part of detox step one:

1. Endotoxins and exotoxins: Toxins produced inside the body through normal biochemical processes.

2. Xenobiotics: Foreign chemical substances found within the body that are not normally produced by, or expected to be present in, the body—and are not a food—that can become harmful if they accumulate within the body.

Today we are going to focus on xenobiotics that can be harmful to your child. You will learn where to find them and how to reasonably avoid them. Many different sources of xenobiotics have been identified that can impact neurological health, endocrine health, and mitochondrial function while decreasing glutathione production, resulting in inflammation and oxidative stress.

A systematic review published in the prestigious Lancet medical journal identified eleven industrial chemicals as developmental neurotoxicants: 2

  • lead
  • methylmercury
  • polychlorinated biphenyls (PCBs)
  • arsenic
  • toluene (ethanol)
  • manganese
  • fluoride
  • chlorpyrifos
  • dichlorodiphenyltrichloroethane (DDT)
  • tetrachloroethylene or perchloroethylene (PERC)
  • polybrominated diphenyl ethers (PBDE)

Of the chemicals and heavy metals listed above, many people believe that their exposure to them is minimal or acceptable. But let’s take a closer look at some of these neurotoxicants.

Lead is first on the list of our detox step one which can be found in household dust, lead paint in older homes (built before 1978), lead crystal, lead ceramics, artificial turf, toys, candies, costume jewelry, contaminated soil and, as Flint, Michigan is now experiencing, in drinking water. There is no known safe level of lead. Exposure occurs via drinking fluids or eating food contaminated with lead, or breathing it in via household dust or outdoor air contaminated by ore and metals processing, leaded aviation fuel, waste incinerators and lead-acid battery manufacturing. Negative impacts of exposure to lead go beyond impairment of neurological health and development. Lead exposure can, depending on the level of severity, adversely affect the nervous system, kidney function, immune system, reproductive and developmental systems and the cardiovascular system. Lead exposure also affects the oxygen carrying capacity of the blood. 3

Mercury comes in two main forms: methylmercury (“organic mercury”), which is typically found in our water supply and has significantly impacted the quality of the fish we eat; and ethylmercury, which is the inorganic form of mercury found in dental amalgams (“silver” fillings) and dental waste, vaccines containing thimerosal, fluorescent light bulbs and ore production. Exposure to mercury occurs when eating certain fish or when chewing with dental amalgams or accidentally breaking a bulb containing mercury.

Polychlorinated biphenyls (PCBs) are now banned, but persist for long periods of time in the environment, and so can be found in contaminated soil and water—and therefore in our drinking water and food.

Arsenic isn’t just in rat poison, it may be found in the chicken you had for lunch. Arsenic is given to young chickens as part of their feed to kill parasites and allow them to grow larger. Because of this treatment, arsenic is also found in chicken faeces, which is used as fertilizer, ending up in the water table and, thus, in our water supply. Arsenic can also be found in rice, particularly in the rice grown in the southern United States in the same fields that previously grew cotton (where arsenic is used as a pesticide). Rice bran, in particular, retains arsenic.

Toluene (ethanol) is used in the manufacture of paints, chemicals, pharmaceuticals, and rubber. Toluene is found in gasoline, acrylic paints, varnishes, lacquers, paint thinners, adhesives, glues, rubber cement, airplane glue and shoe polish. It is the neurotoxicant that gives a “high” when glue sniffing. Due to genetic polymorphisms, some people may be more sensitive to the effects of inhaled solvents than others. 4

Manganese is the only neurotoxicant on the list which is a known necessary substance for the human body. However, in excess manganese has a severe and detrimental impact on neuronal health. Manganese is added to gasoline (it replaced lead when lead was banned from gasoline). Cars release manganese into the atmosphere. When it rains, manganese is recycled back down into the water table. When manganese is suspended in water it is more bioavailable and therefore both drinking and bathing in water with excess bioavailable manganese levels can increase exposure and have a significant impact on our children’s health.

Fluoride as a toxicant may come as a surprise to you. We add fluoride to our water and toothpaste and use it in dental treatments to prevent tooth decay, and have been told for years that these practices are healthy. But there is much debate over the safety of fluoride—in particular the safety of it in our drinking water. In fact, fluoride is known to be a neurotoxicant and has also been found to be an endocrine (hormone) disruptor.

Chlorpyrifos is an insecticide currently used in agriculture. Although it was previously used as a household insecticide, it has since been banned from residential use due to its neurotoxic effects.

Dichlorodiphenyltrichloroethane (DDT) was once one of the most widely used pesticides in the world. Even though is it now a banned substance in most Western countries, it is still in use in many areas of the world and is widely found in the food supply due to its persistence in the environment (it breaks down VERY slowly) even in areas where it has been banned for many years. DDT continues to be found in samples of human blood, according to the CDC’s National Biomonitoring Program.

Tetrachloroethylene or perchloroethylene (PERC) is a neurotoxicant found in the chemicals used to dry clean clothing. It off-gasses (gives off fumes) and impacts air quality for hours after the clothes have been cleaned. One study prompted by a 15-year-old girl who solicited the help of the former Chair of Georgetown University’s chemistry department, showed that clothes that have been repeatedly dry cleaned retain a significant amount of PERC after cleaning. 5

Polybrominated diphenyl ethers (PBDEs) are flame retardants that are often found in mattresses, furniture, upholstery, electronics, and plastics. These chemicals prevent the spread of flame by creating a bromide “cloud” around the object that it has been applied to. PBDEs are often found in tests of household dust and, in turn, impact indoor air quality.

“Strong evidence exists that industrial chemicals widely disseminated in the environment are important contributors to what we have called the global, silent pandemic of neurodevelopmental toxicity.”  6

In addition to the neurotoxicants above, other substances impact different systems in the body and impair glutathione production (which impairs your child’s detox capacity).

Tylenol (acetaminophen or paracetamol) has been shown to deplete intercellular (available) glutathione. 7  Glutathione is the body’s master antioxidant and is required in many detoxification functions in the body. A review of studies examining the role of glutathione in detoxification and autism spectrum disorder concluded that children with ASD have altered glutathione metabolism. 8

BPA and BPA-free plastics, the last on the list of detox step one, are known endocrine disruptors. Almost all commercially available plastic products sampled in a independent study—no matter the type of resin, product or retail source—leached chemicals having reliably detectable estrogenic activity, including those advertised as “BPA-free.” Estrogenic activity interferes with the body’s normal hormone activity, which can affect a wide array of bodily systems due to the important regulatory effects of hormones. In some cases, BPA-free products released chemicals with even more estrogenic activity than did BPA-containing products. 9. The endocrine (hormone) system is typically already in a challenged state in children with neurodevelopmental disorders. Exposure to this type of toxicant adds fuel to the fire.

Sadly, the list above is just the beginning, hence, detox step one. There are too many toxicants to discuss in one article, but eliminating or minimizing exposure to the ones above will help improve the health of your child and your whole family. Take a home and school inventory to determine where you may need to focus your attention to reduce potential toxicants included in detox step one which your child may be exposed to.

14 Steps You Can Take Right Now to Reduce Your Child’s Exposure to Toxicants

  1. Household cleaners can have many harmful ingredients that increase your child’s total body burden over time. Take an inventory of what is in your cleaning closet and compare it to the Environmental Working Group’s ratings of cleaning products. Even better, start from scratch and make your own household cleaners from simple and inexpensive ingredients.
  2. Check the ingredients of personal care products. Unfortunately, most store-bought products contain harmful ingredients, although there are many DIY recipes and increasingly more ready-made products with less harmful ingredients available in stores.
  3. Find an eco-friendly dry cleaner or hang dry cleaned clothes outside to off-gas for a day after cleaning.
  4. Eat organic whenever possible. Check out the Environmental Working Group’s Dirty Dozen and Clean Fifteen lists to find out which fruits and vegetables are most important to buy organic.
  5. Avoid eating fish high in mercury. Use the Environmental Working Group’s Consumer Guide to Seafood to determine what fish are safest to eat.
  6. Get a water filter for your home. A whole-house filter is ideal for reducing exposure to any toxicants through the skin or by drinking.
  7. Get a HEPA air filter or equivalent for your home. This will take some research but as many of the indoor toxicants are airborne, it is worth the effort. Indoor air quality can also be improved with appropriate houseplants and salt lamps.
  8. Do not use pesticides inside or outside of your home. If you have a pest problem, investigate natural options.
  9. Store food in glass instead of plastic. Never heat food in plastic.
  10. Use reusable water bottles and mugs made of glass or stainless steel.
  11. Avoid Teflon. Use stainless steel, cast iron or glass cookware.
  12. Take off your shoes before entering your home (make it a household rule!), and wipe off your pets' feet in order to minimize any toxicants entering the home from outside (e.g. pesticides from neighbouring homes).
  13. Evaluate whether your mattresses, furniture, upholstery or even clothing your child (and the rest of your family) is exposed to contain flame retardant chemicals. It may be time to start researching a new mattress or two in your home.
  14. Eliminate use of Tylenol. Acetaminophen depletes glutathione, which is a necessary agent in detoxification.

We cannot possibly eliminate all toxicant exposures, but each small step adds up to less of a burden on your child’s detox system. Don’t become overwhelmed by this process. Besides, detox step one is just the beginning our our detox journey. Over time, if you work on the items above you will be creating a healthier environment for your family. Remember to take each step slowly and hopefully in this blog, Detox Step One: Reducing Child Exposure to Toxicants, it has helped to untangle the confusion. Let me know in the comments below what you do to minimize your child’s toxic burden and what is still a challenge.


  1. (Grandjean, P and Landrigan, PJ. Neurobehavioral Effects of Developmental Toxicity. Lancet. 2014; 334
  2. (Grandjean, P and Landrigan, PJ. Neurobehavioral Effects of Developmental Toxicity. Lancet. 2014; 334 – updated from the 2006 review). 
  3. https://www.epa.gov/lead-air-pollution/basic-information-about-lead-air-pollution#how  
  4. Broberg K, Tinnerberg H, Axmon A, Warholm M, Rannug A, Littorin M. Influence of genetic factors on toluene diisocyanate-related symptoms: evidence from a cross-sectional study. Environ Health. 2008 Apr 30. 7:15
  5.  Sherlach, K. S., Gorka, A. P., Dantzler, A. and Roepe, P. D. (2011), Quantification of perchloroethylene residues in dry-cleaned fabrics. Environmental Toxicology and Chemistry, 30: 2481–2487. doi:10.1002/etc.665 
  6. Grandjean, P and Landrigan, PJ. Developmental neurotoxicity of industrial chemicals. Lancet.2006; 368: 2167–2178 
  7.  Acetaminophen Toxicity, Journal of Biological Chemistry, Vol. 274, No. 15, Issue of April 9, pp. 10349–10355, 1999 
  8.  The potential role of the antioxidant and detoxification properties of glutathione in autism spectrum disorders: a systematic review and meta-analysis, Main PA, Angely ME, O’Dohrety CE, Thomas P, Fenech M, Nutr Metab (Lond). 2012 Apr 24;9:35. 
  9. Environ Health Perspect 119:989-996 (2011)